Garlic attenuates cardiac oxidative stress via activation of PI3K/AKT/Nrf2-Keap1 pathway in fructose-fed diabetic rat.

Garlic attenuates cardiac oxidative stress via activation of PI3K/AKT/Nrf2-Keap1 pathway in fructose-fed diabetic rat.

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BackgroundCardiovascular complication due to diabetes has remained a major cause of death.There is an urgent need to intervene the cardiac complications in peoria orange barrels diabetes by nutritional or pharmacological agents.Thus the present study was designed to find out the effectiveness of garlic on cardiac complications in insulin-resistant diabetic rats.Methods and resultsSD rats were fed high fructose (65%) diet alone or along with raw garlic homogenate (250 mg/kg/day) or nutrient-matched (65% corn starch) control diet for 8 weeks.Fructose-fed diabetic rats showed cardiac hypertrophy, increased NFkB activity and increased oxidative stress.

Administration of garlic significantly decreased (pConclusionOur study demonstrates that raw garlic homogenate is effective in reducing cardiac hypertrophy and fructose-induced myocardial oxidative stress through deroyal finger spring PI3K/AKT/Nrf2-Keap1 dependent pathway.